Research

In vitro bone mechanobiology

In the area of in vitro mechanobiology of osteocytes, osteoblasts and osteoclasts, we have developed both two-dimensional (2D) and three-dimensional (3D) models for testing a series of novel hypotheses regarding the role of the osteocyte network in sensing mechanical signals and regulating osteoblast or osteoclast functions...

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Research

Quasi-3D cell mechanics

We have recently developed a novel quasi-3D microscopy system for the study of cells under fluid flow. This novel technology provides an amazing ability to simultaneously visualize and quantify, in real-time and in 3D, the dynamics of two cytoskeletal components and signal activation via fluorescence resonance energy transfer (FRET)...

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Research

ITS and FEA of Skeletons

In the area of image based microstructural and finite element analyses of human skeletons, we have innovated and advanced an individual trabeculae segmentation (ITS) technique and demonstrated its unique power in basic micromechanics of human trabecular bone...

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